Bioscience is a vast puzzle, which sounds like fun—until you remember that puzzles can be frustrating, especially if they’re missing crucial pieces. Fortunately, as this issue of GEN indicates, some of bioscience’s missing pieces are falling into place. Piece one: The tissue-level patterns formed by cells with disparate gene expression profiles. (These patterns, which influence health, are emerging because single-cell technology is being combined with spatial transcriptomics.) Piece two: A smooth Design-Build-Test-Learn (DBTL) cycle in synthetic biology. (DBTL still isn’t turning as freely as it might, but with new DNA-writing technology, more RPMs are expected.) Piece three: CAR T cells that could help more than a minority of cancer patients. (Such cells may be built if allogeneic approaches are used, or if genetic engineering is used to install ancillary immune signals.) So, if you want to solve bioscience puzzles—including those related to outsourcing and bringing NGS to bear in biomanufacturing—read our September issue.