Bacillus subtilis

A Novel Endotoxin-Free Microbial Expression System

Lack of pathogenicity and other advantages over Escherichia coli make Bacillus subtilis an attractive host expression system, says GenScript, especially if secretory capacity is enhanced.
scientists in clean room

How Effective Buffer Management Facilitates Biopharmaceutical Production

Biopharmaceutical production depends on buffers. Making sure the right buffer solutions are available, in the right place on the manufacturing line, at the right time, and in the right quantity, is a considerable challenge.
microprotein PIGBOS

Microprotein Could Point to New Therapeutic Targets for Diverse Human Diseases

Study results indicate that a previously uncharacterized 54 amino acid microprotein called PIGBOS sits on the outer mitochondrial membrane and plays a key role in modulating the unfolded protein response, or UPR, which mitigates a form of cellular stress. Dysregulation of UPR is thought to underpin a range of diseases including Alzheimer's disease and other neurodegenerative disorders.
Close up of liquid in pipette

Process Guidance: Cellvento® 4CHO Fed-batch Medium

Sponsored content brought to you by Mammalian cell expression systems are the dominant tool today for the production of complex biotherapeutic proteins. Different CHO hosts are used routinely to develop such biologics and are combined...

Synthetic Biologists Develop an Ear for the Language of Proteins

A deep-learning based computational approach called unified representation, or UniRep, has been used to distill the fundamental features of a protein from the protein’s unlabeled amino acid sequences. UniRep promises to accelerate the design of synthetic proteins that possess desirable functions in varied biomanufacturing applications.

Danaher Selling Off Some Businesses to Sartorius for $750M, Tying the Deal to GE...

Danaher has agreed to sell three of its life sciences tools businesses to Sartorius Stedim Biotech for approximately $750 million cash—a deal that according to Danaher was prompted by its planned $21.4 billion acquisition of GE Life Sciences’ Biopharma business.

GE Healthcare, NIBRT Partner on Cell Therapy, Single-Use Bioprocessing

GE Healthcare (GEHC) and Ireland’s National Institute of Bioprocessing Research and Training (NIBRT) are partnering to deliver educational training programs focused on biopharmaceutical and cell therapy development and manufacturing, building on a two-year-old collaboration.

The Combination of Ubiquitous Chromatin Opening Element (UCOE®) Expression Technology with the CHOZN® Platform...

In this study MilliporeSigma's goal was to modify a well-defined cell line development system to generate high performing recombinants in a time- and resource-efficient manner.
Lab research

Case Study: Accelerate the Time from DNA to Material

In this MilliporeSigma sponsored content, we explores they'r mini-pool approach as fast track process for small biotechs who are on a very challenging timeline. It enables us to start process development and production of early material before cell line development is completed.
Glycosylation enzyme molecule

Successfully Addressing the Challenges of Glycosylation

Post-translational modification is a critical step in the synthesis of biotherapeutic molecules. Among these alterations to the original naked protein, glycosylation may be the most significant and difficult to properly complete. In this roundtable, we discuss the challenges and the pitfalls involved in generating authentic glycosylated molecules in cell culture and microbial production facilities

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