“Anti-Evolution Drugs” Could Offer New Strategy against Antimicrobial Resistance Crisis
The battle between medicine and harmful bacteria has traditionally centered on the hunt for new antimicrobial drugs, but the pathogens almost inevitably develop resistance...
Triple-Negative Breast Cancer in Mice Inhibited by Migraine Drug
A drug previously approved for treating migraine and epilepsy has been found to slow the growth of triple negative breast cancer in mouse models. Researchers carried out screening studies to identify known pharmacologically active compounds that trigger degradation of N-Ras, a key protein that drives the development of aggressive basal-like breast cancer.
AstraZeneca’s Imfinzi Fails 2nd Primary Endpoint in Phase III MYSTIC Trial
AstraZeneca and its MedImmune subsidiary acknowledged today that their marketed anticancer treatment Imfinzi™ (durvalumab) failed the second of two primary endpoints in a Phase III...
Cell Therapy Manufacturing: The Supply Chain Challenge
The success of cell therapies hinges on not only proving that a product elicits the desired biological response, but also overcoming the challenges of manufacturing and administering a complex product to any patient.
Herbal Folk Remedy Molecular Mechanisms Uncovered
Traditional herbal medicines used for centuries often have tangible physiologic and therapeutic value. Yet, for these remedies to be successful for the masses the...
Norovirus Insights May Improve Conditions Below Deck
Centers for Disease Control and Prevention (CDC) research highlights several factors that can make norovirus outbreaks more severe and may help guide efforts to develop a vaccine. The disease spreads through direct contact with an infected person, consuming contaminated food or water, or touching contaminated surfaces.
The Evolution of Biobanking
Improvements in our understanding of disease have relied primarily on clinical trials backed by real-world evidence. Biological samples and large-scale datasets are key components...
Drug Discovery Turns to Smart Throughput
High-throughput screens generate lots of hits, but few of these hits make much of a dent against disease mechanisms. To get more bang for the discovery buck, invest screening with more intelligence.
Finding Sense in Sequences
According to Dotmatics, objective analysis of complex and high-dimensional data can inform design changes, cycle by cycle, refining sequence-based structures and optimizing drug leads.
Celgene, Dragonfly Expand Cancer Immunotherapy Collaboration
Dragonfly Therapeutics said today it has doubled to eight the number of its natural killer (NK) cell engager cancer immunotherapy candidates available for in-licensing...
