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Call it another iteration of the industrial revolution: T cells equipped with chimeric antigen receptors (CARs) are starting to roll off assembly lines. Unlike the Model T, which was said to come in any color (so long as it was black) the CAR T needs to be exquisitely personalized. Also, the CAR T needs to be loaded with safety features. To learn about progress on all these CAR T-cell challenges, hop into the May issue of GEN, which not only tours the CAR T landscape, it also explores the highways and byways of kinase assay development, antibody characterization, and multiplexed biomarker interpretation. Finally, this issue offers readers several roadside attractions, none more engaging, perhaps, than a pair of CRISPR base editors.

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