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In this issue of GEN, the cost of sequencing a genome has been coasting down from $1000 and is heading toward $100. The announcement of germline-edited CRISPR twins in China once again highlights the need for regulation into this emerging arena. This month’s A-List covers the Top 25 biotech companies of the past year. And PATH—a new organization promoting the use of AI, robotics, and genomics in healthcare—is profiled.