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Stop flying blind! That, in brief, is the message offered by GEN’s March issue, which warns that if we are to effectively pilot the nation’s anti-COVID-19 efforts, we need to see what we’re up against—a darkening swarm of SARS-CoV-2 variants. To date, we haven’t been taking full advantage of the nation’s sequencing prowess. It is almost as if our air defense systems had neglected to light up their radar screens. The importance of situational awareness also figures in our March issue’s coverage of immune profiling and genome editing. With immune profiling, deeper and higher-dimensional analysis of T- and B-cell attributes—and the spatial distribution of immune cell subpopulations—can improve the design and deployment of cancer immunotherapies. And with genome editing, we may seize opportunities to suppress dangers before they take wing. How? Use base editing techniques to avoid double-strand breaks, which may cause unwelcome off-target effects. Navigational assistance is also available from artificial intelligence, which is being applied in genomic medicine. As the March issue indicates, we’re not ready to cruise the genome on autopilot, but soon we may guide therapeutic payloads more effectively—provided we amass the data we need and process it through sufficiently powerful computational resources.