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Interrogating the Immunology of Infectious Disease with Single-Cell and Spatial Multiomics

In this GEN webinar, sponsored by 10x Genomics, we will discuss the utility of single-cell and spatial multiomics technologies to advance infectious disease and immunology research, highlighting how the scientific community can respond to such events as the COVID-19 pandemic.

Revolutionizing Fermentation In-Process Monitoring

In this GEN webinar, sponsored by Genentech and Custom Biotech, our panelists will describe their approach to evaluating the Cedex Bio/Bio HT analyzers for E. coli fermentation, and their impact on turnaround time and cost of analysis.

Shedding New Light on GPCR Drug Discovery with a Novel Biosensor Technology

In this GEN webinar, sponsored by Domain Therapeutics, we will discuss how the use of enhanced bystander bioluminescence energy transfer (ebBRET) biosensors and tag-free G protein coupled receptors (GPCRs) can help empower the discovery of next-gen therapeutics.

Cell Lines for Optimizing Biotherapeutic Production Workflows

In this GEN webinar, sponsored by Horizon Discovery, our presenters will discuss their process for evaluating growth conditions, transfection methods, clonal cell line development, and productivity assessments. We will also hear about the gene-editing options available to customize expression hosts to suit specific needs during discovery, development, and protein production.

Heroes and Villains: Reflections on the CRISPR Revolution

Kevin Davies, PhD, founding executive editor of The CRISPR Journal, has chronicled these events in his new book, Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing. This GEN keynote webinar takes place on the official publication day of the book. Davies will share highlights and insights from his reporting over the past few years and consider some of the exciting new directions that CRISPR will empower in the years ahead.

Advances in AAV Vectors and Gene Therapy

In this timely GEN Keynote webinar, sponsored by Aldevron, renowned AAV pioneer Dr. Guangping Gao (UMass Medical School/editor, Human Gene Therapy) will discuss the principles, history, challenges, and future directions of human gene therapy using AAVs. Dr. Gao will focus on progress in treating rare diseases and detail AAV capsid engineering to modulate target tissue tropism, therapeutic gene expression, and cassette design/optimization. Dr. Gao will also share examples of AAV gene therapy development: from proof-of-concept preclinical studies to first-in-human clinical evaluation.

The Secret to Improving the Therapeutic Index of Antibody Drug Conjugates

REGISTER NOW Broadcast Date: February 5, 2019 Time: 8:00 am PT, 11:00 am ET, 17:00 CET Antibody-drug conjugates (ADCs) were initially developed to provide a selective targeting...

Preventing Dementia through a Virtual Twin Brain

GEN's on demand webinar, sponsored by Dassault Systèmes, discusses the current state of The Living Brain Project and how it is being applied to traumatic brain injury, neuromodulation, neurodegenerative disease progression, and drug delivery through cerebrospinal fluid.

Streamlined Formulation of Enzyme Products

REGISTER NOW Broadcast Date: February 26, 2019 Time: 8:00 am PT, 11:00 am ET, 17:00 CET There are two complementary paths to creating a stable enzyme formulation....

How to Decrease Long Read Sequencing Sample QC Time by 10-Fold

This presentation will show how low concentrated samples, as well as libraries prepared for long read sequencing benefit from QC, performed with the Femto Pulse.

Association Rate Constant: The Unsung Hero of Drug Discovery Kinetics

While the importance of ligand-receptor binding kinetics on drug action is becoming well established, focus to date has been almost entirely on the role of the dissociation constant on drug efficacy and duration of action. The association rate constant, in contrast, has been largely overlooked, with many investigators still considering it diffusion-limited and equivalent across a compound series. This GEN webinar aims to remedy that by turning the spotlight onto the undervalued and oft-ignored association rate constant.

Recent Advances and the Future of Antibody Engineering

In this GEN webinar, we will hear from Danica Stanimirovic MD, PhD, and Danica Stanimirovic MD, PhD, wto leading scientists who will describe their current antibody engineering research projects and the therapeutic potential they hold.

Pancreatic Cancer Therapeutic Target Visualized Using In Situ Hybridization

In this GEN webinar sponsored by Advanced Cell Diagnostics, we will hear about new PDAC research showing that the cytokine leukemia inhibitory factor (LIF) key paracrine factor from activated pancreatic stellate cells acting on cancer cells.

Measuring Multivalent Interactions: Uncovering the Secrets of Virus Binding Strategies

In this GEN webinar, we will learn from Dr. Daniel Lauster, who, when faced with many of the challenges described above, utilized MicroScale Thermophoresis (MST) to measure the interaction between more than 100 novel non-toxic multivalent nanoparticle-conjugates and intact IAV in solution with as little as nanomoles of nanoparticles. Additionally, we will hear from Dr. Matthias Molnar how MST is becoming scientists’ first choice for the characterization of molecular interactions thanks to its flexible throughput, low sample consumption, and measurements in solution or in close to native conditions.

Mind the Yap! Single-Cell Transcriptomes Reveal Drivers of Intestinal Regeneration

In this GEN webinar, we will hear about recent findings implicating the Hippo effector, Yap, as a driver of a novel damaged-induced intestinal stem cell population.

Managing Multiple Biomarker Therapeutic Development

In this roundtable, our panelists will discuss assessing the validity of biomarkers to inform drug development and potential combination therapies. Key considerations include predictive testing of biomarkers, analytical methods, drug-diagnostic co-development and potential reimbursement considerations.

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