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mRNA Applications Beyond COVID-19

Researchers push the boundaries of mRNA technology, creating market opportunities across a range of therapeutic modalities. Progress in each of these modalities depends on research advancements, examples of which make up the bulk of this eBook sponsored by Thermo Fisher.
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Advances in Live-Cell Biological Image Analysis

This eBook, sponsored by Sartorius, explores how live-cell imaging and analysis technologies enable more objective and quantitative analysis, leading to deeper insights while supporting scientific research at scale. In general, these technologies are grounded in image segmentation, that is, the digitalized and automated recognition of individual cells or, rather, cell boundaries. 
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The Changing Landscape of CRISPR Screening

This eBook, sponsored by Twist, offers a contemporary synthesis of CRISPR screening technologies for functional geneticists. In the chapters that follow, we’ll dive deeper into some of the most recent advances in the field, we’ll see how the technologies are being used today, and we’ll highlight CRISPR experiment design tips from leading experts in the field to help scientists see success with the next generation of functional genomic screens.

The Way Forward: Taking a Closer Look at AAV Manufacturing Processes

Stories in this eBook, sponsored by Thermo Fisher, may serve to remind readers that AAV advances seldom occur in isolation. They draw on varied technological developments, some rarefied. More important, they point to varied possibilities, none more essential than the  development of life-saving treatments.
Human Stem Cells

Superpowered Cell Therapies: The Role of Single-Cell Proteomics

In this eBook, sponsored by Isoplexis, we will cover recent cutting-edge research in cellular therapy, as well as several cases in which functional proteomics technology was used to optimize cell therapies at every stage of the development pipeline, filling critical gaps in cell therapy product quality assessment and predictive biomarker discovery.

Understanding the Role of Polyfunctional Immune Cells in Cancer and Other Diseases

This roundtable, sponsored by Isoplexis, highlights how scientists are mining single-cell proteomic data to identify and understand dynamic proteomes in high-functioning immune cells and their immune impact. Our expert panel discusses the development of new cell and immune therapies that target tumors, based on the insights gleaned from proteomic profiles of multifunctional immune cells.
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Accelerating Drug Discovery through Systematic Cell and Protein Analysis

Creative endeavors—including drug discovery—bring to mind that old saying, “Think outside the box.” That’s a good saying, but when the box is the human cell, it is necessary to think inside the box, too. Also, it helps to think about what’s within. In this eBook, sponsored by Sartorius, we consider all these perspectives.
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Detecting HCP Impurities in the Bioproduction Haystack

This eBook, sponsored by Cytiva, dives into some of the current challenges that biomanufacturers face when analyzing their production streams for impurities and what they are doing to improve detection methodologies for HCPs.
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PCR: The Ubiquitous Molecular Biology Workhorse Reasserts its Continued Relevance

In this eBook, sponsored by Thermo Fisher Scientific, we examine the rising role of genetics in medical diagnostics, including polymerase chain reaction (PCR), genomic sequencing, and gene-based microbiome disease association. This collection of articles looks at the dramatic increase in prevalence of PCR testing since the onset of the COVID-19 pandemic, and explores the possibilities of still deeper, wider spread clinical applications for PCR in the not-so-distant future.
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mRNA Vaccines: A New Era of Biotherapeutic Development

2020 was devastating. It was also a year of firsts. Fueled by decades of research and widespread global cooperation, the first mRNA-based vaccines against SARS-CoV-2 were produced, tested, and injected mere months after COVID-19 hit. With mRNA technology proven, the floodgates are now open to a deluge of possibilities. We’ve got some of the brightest and most industrious on the case to solve the challenges unique to mRNA. Read this collection of articles to join the mRNA evolution and bring more ‘firsts’ to patients.