MilliporeSigma has introduced a portfolio of bio-based solvents for high performance liquid chromatography (HPLC), manufactured from renewable feedstocks as drop in alternatives to conventional HPLC grade acetonitrile, methanol, and ethanol. The solvents are designed to match the performance of existing materials and are compatible with established HPLC and LC MS methods, allowing laboratories to use them in routine and regulated analytical workflows. They can be applied in separation and quantification tasks across drug development, manufacturing quality control, environmental monitoring, and diagnostic testing.