Advion sample-introduction technology to be combined with Waters ion mobility-based separation system.

Waters and Advion Biosciences successfully completed the evaluation phase of a joint effort to integrate the Advion TriVersa NanoMate chip-based infusion technology with the Waters® Synapt High Definition MS™ System.

The companies say the collaboration will maximize the amount of information researchers can extract from complex samples by combining the ease-of-use and reproducibility of Advion’s nanoelectrospray chip-based sample introduction technology with the additional dimension of ion mobility-based separation provided by the Waters Synapt™ HDMS System.

The Synapt HDMS System combines high-sensitivity ion mobility and tandem mass spectrometry to provide information that is beyond the capabilities of conventional mass spectrometers, namely its ability to probe the size and shape of ions, says Alan Millar, HDMS program manager at Waters.

“A prerequisite for many investigations of this type is the ability to maintain the native conformation of protein or peptide ions into the gas phase. This is typically achieved through the use of neutral pH solvents and low infusion flow rates; an area where the TriVersa NanoMate system can provide demonstrable benefits in terms of ease-of-use and reproducibility,” says Jack Henion, Ph.D., co-founder, CSO, and chairman of Advion BioSciences.

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