Peptide mapping is an essential step in characterizing, identifying, and monitoring a wide range of properties of target proteins in biotherapeutic studies.
Peptide mapping for biotherapeutic proteins relies on protein digestion which includes the enzymatic treatment of a protein to produce peptide fragments to further characterize specific peptide regions and modifications. The results of these protein digests are critical for protein structural characterization, protein identification, and protein modification monitoring including post-translation modifications, product related impurities, and multi-attribute monitoring (MAM) methods. However, sample preparation for peptide mapping is often complex and laborious with long digestion times.
The resources here are intended to help simplify your peptide mapping, reduce digestion times and improve results. Read on for more information.