October 1, 2011 (Vol. 31, No. 17)

Biological Databases for Life Science Research

BIOBASE is a leading provider of expert-curated biological databases, software, and services for the life sciences. Our products and services identify relations critical to drug and biomarker discovery as well as improve biomedical research by transforming data into scientific knowledge. Our customers resolve information challenges and achieve better outcomes faster.

Today’s researcher is challenged to successfully navigate the flood of data resulting from an ever increasing number of publications as well as large datasets generated from next-generation sequencing (NGS), microarray, RNA-Seq, and other high-throughput techniques. BIOBASE’s suite of products provides the solution to this challenge.

BIOBASE provides well-structured data, assembled by highly qualified subject-matter experts, organized in an accessible and easily searchable manner that enables researchers to access the scientific results gathered by generations of dedicated scientists in order to identify connections between disparate pieces of information. Our companion analysis tools allow researchers to analyze their own experimental results in the context of published information and to apply that knowledge to their specific topic of interest.

Markets Served

BIOBASE is headquartered in Wolfenbüttel, Germany, with branch offices in the U.S., India, and Japan. BIOBASE serves more than 600 customers worldwide, including pharmaceutical, academic, and research institutions. We offer a broad and flexible range of solutions that can be customized to individual needs, including non-profit research institutes, academic labs, universities, and computational biologists in the life science industry.


BIOBASE offers comprehensive solutions to life science researchers. Our databases contain expert-curated biological information that works with included analysis tools for human mutation, gene regulation, and functional analysis to generate maximum value from your experimental data.

BIOBASE’s Genome Trax™ enables you to identify human genome variations of functional significance by mapping your next-generation sequencing (NGS) data to known elements such as disease mutations and regulatory sites. For human gene mutation BIOBASE’s HGMD® Professional provides comprehensive data on human inherited disease mutations to genetics and genomic research. It is widely used in human genetics research, diagnostics, and personal genomics applications.

BIOBASE’s powerful ontology search query system, PROTEOME™, with specialized tools for gene set analysis and pathway visualization, allows scientists working with mammalian, yeast, worm, and plant species to quickly find answers to questions relevant to their research.

Finally, TRANSFAC® and ExPlain™ offer the most comprehensive collection of eukaryotic gene-regulation data in combination with advanced analysis tools. TRANSFAC is a knowledgebase containing data on eukaryotic transcription factors, their experimentally proven binding sites, and regulated genes. Promoter analysis of high-throughput data based on TRANSFAC positional weight matrices is provided in the accompanying ExPlain™ Analysis System, a unique data-analysis platform that combines promoter and pathway analysis tools. ExPlain™ enables you to identify transcription factors affecting gene expression in your microarray and RNA-Seq experiments, as well as predict how they, acting in combination, can induce observed gene expression patterns.

For researchers with specialized needs, we offer custom curation and analysis services. Through custom curation services we apply our expertise in data extraction and management to the topic of interest to you, while through custom analysis services we leverage our experience in data analysis to bring meaning to your high-throughput datasets. Together our products and services help researchers make sense of the overwhelming amount of published and experimental data to identify relations critical to drug and biomarker discovery.


100 Cummings Center

Suite 107A

Beverly, MA 01915

Phone 978.922.1643

Website www.biobase-international.com

Date Founded 1997

Number of Employees 130

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