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Spatial omics is transforming how researchers understand tissue biology, revealing the complex interplay between cells in health and disease. While RNA expression studies provide important molecular insights, proteins execute the functions that drive cellular behavior, signaling, and therapeutic response. Profiling proteins in situ, at high resolution, and across diverse tissues offers the opportunity to uncover disease mechanisms, characterize rare cell populations, and generate translationally relevant discoveries that RNA alone cannot reveal. Researchers need tools that enable high-plex, high-sensitivity, and high-throughput protein profiling within intact tissue architecture.

A new benchmark for biomarker discovery

Leveraging the widely adopted GeoMx^® Digital Spatial Profiler (DSP), the GeoMx Discovery Proteome Atlas (DPA) from Bruker sets a new standard for spatial proteomics. GeoMx DSP already enables scientists to profile RNA and proteins directly in tissue with high throughput and reproducibility. GeoMx DPA dramatically expands those capabilities: It is the largest commercially available, antibody-based spatial proteomics assay offering more than 1200 curated protein targets, including over 130 post-translational modifications, to deliver unprecedented depth and coverage.

What distinguishes GeoMx DPA is its careful curation. Each protein has been selected for relevance across 40 tissues and more than 120 biological processes in oncology, immunology, and neuroscience. Validated antibody clones provide confidence in data quality and simplify follow-up validation.

Beyond scale and content, GeoMx DPA offers unique technical benefits. Proteins can be spatially resolved ranging from tumor niches to rare cell populations to single cells. Multiomic integration with the GeoMx Whole Transcriptome Atlas allows RNA and protein to be analyzed in parallel at extraordinary scale, providing a complete picture of molecular programs in spatial context. Users also retain the ability to add up to 40 custom protein targets via the Protein Barcoding Service, without changing established workflows or throughput.

Together, these features make GeoMx DPA the most comprehensive and practical solution for high-plex spatial proteomics.

Confidently driving discovery and translation forward

GeoMx DPA is designed not just to expand scale but to deliver scientifically rigorous, actionable insights. Its content consists entirely of Abcam-validated RabMAb^® antibodies tested to perform reliably in both single-plex and multiplex formats, ensuring robust detection of protein expression. This validation gives researchers confidence that measured proteins reflect true biology, even in rare cells or single-cell analyses.

Benchmarked against independent RNA-seq and mass spectrometry datasets, GeoMx DPA demonstrates a strong correlation with established transcriptomic and proteomic profiles while adding the critical advantage of spatial context. These results demonstrate that GeoMx DPA achieves high-plex, high-sensitivity protein detection without compromising accuracy or reproducibility.

GeoMx DPA bridges discovery and translational research. Researchers can identify signaling events invisible to RNA, characterize functional immune subsets, and track post-translational modifications that reflect pathway activation and disease state. Because all antibodies are also available as individual reagents, discoveries in high-plex mode can be quickly confirmed by flexible, subcellular-resolution imagers like the CellScape™ platform, streamlining orthogonal biomarker validation and reducing translational bottlenecks.

Shaping the future of spatial biology

By combining curated high-plex content, single-cell resolution, and seamless multiomic integration, GeoMx DPA opens a frontier for discovery and translation in spatial biology. For the first time, researchers can interrogate more than 1200 proteins in spatial context while simultaneously mapping the transcriptome, providing a level of clarity that reshapes what is possible in biology.

Learn more brukerspatialbiology.com.

GeoMx DPA is for Research Use Only. Not for use in diagnostic procedures. RabMAb^® is a registered trademark of Abcam.