Genetic Engineering and Biotechnology News

Future of Pharmaceuticals

Radiopharmaceutical Pathways: Ensuring Precision from Logistics to Manufacturing

Credit: Marken

Panelists:

Image of Tom Brennan

Tom Brennan

VP Nuclear Medicine
Marken

Panelist

Image of Tom Brennan

Tom Brennan

Tom Brennan is vice president of Nuclear Medicine at Marken-UPS Healthcare Precision Logistics and brings a wealth of experience from more than 30 years in life science supply chains. He previously spent two decades at AirNet Systems, leading medical cargo operations and creation of the Life Sciences division. Featured on the History Channel’s “Dangerous Cargo,” Brennan is known for developing tailored logistics solutions, building high-performing teams, and driving growth in nuclear medicine, transportation, and regulatory-compliant supply chain strategy.

Image of John Zehner

John Zehner

President and CEO
SpectronRx

Panelist

Image of John Zehner

John Zehner

John A. Zehner, CEO of SpectronRx, is a Purdue‑trained nuclear pharmacist with over 30 years of leadership in isotopes, radiopharmaceutical development, and biotech ventures in the U.S. and Europe. He co‑founded Eastern Isotopes (later acquired) and previously led Zevacor Molecular as COO. At SpectronRx, he drives innovation in targeted radiotherapies, oversaw the first privately held commercial cyclotron‑based production of Ac‑225 from Th‑232, and successfully navigated regulatory milestones—including FDA and NRC approvals—for world‑class isotope manufacturing operations.

Broadcast Date: 
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Radiopharmaceuticals have been on the market for decades, and in the era of personalized medicine, interest in them is growing because of their ability to treat patients with unprecedented accuracy. However, realizing their potential in clinical practice depends on overcoming a supply chain of unparalleled complexity, where precise timing is paramount. The challenge is immense: these life-saving therapies have a half-life measured in days, hours, or mere minutes. From the moment a dose is manufactured, the clock starts ticking, demanding a detailed logistical framework that operates with surgical precision.  

In this GEN webinar, our expert speakers—Tom Brennan (VP Nuclear Medicine at Marken-UPS Healthcare Precision Logistics) and John Zehner (CEO/President of SpectronRx)—will describe the extraordinary journey of a radiopharmaceutical dose and explore the sophisticated dance of just-in-time manufacturing, real-time GPS and temperature tracking, and the intricate coordination required between production facilities, specialized couriers, and clinical teams. Viewers will gain a deeper understanding of the technology and operational expertise required to navigate the challenges of ultra-short shelf lives, ensuring these potent treatments reach patients exactly when needed to deliver the highest possible efficacy.

Key Takeaways: 

  • Understand why the ultra-short half-life of radiopharmaceuticals creates an unprecedented logistical challenge, making every minute from production to treatment critical.
  • Get an inside look at the essential components for the supply chain, including advanced technology, innovation, and operational strategies coordinated to ensure on-time delivery.
  • A clear appreciation for the orchestration required between stakeholders to make these therapies a reality for patients.  
  • The coordination and intricacies of both raw materials and patient-ready doses (PRDs).

A live Q&A session followed the presentation, offering a chance to pose questions to our expert panelists.

Produced with support from:

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