In the rapidly evolving field of lipid nanoparticle (LNP) research, the integration of advanced technologies is crucial for the efficient generation, screening, and characterization of formulations.

In this GEN webinar, our expert speakers will explore a connected workflow of innovative methodologies employed to develop and screen LNP formulations using the Sunscreen high-throughput screening (HTS) equipment from Unchained Labs, in conjunction with the LipidBrick^® library from Sartorius Polyplus, a novel range of proprietary cationic lipids. Attendees will gain insights into the characterization of LNPs utilizing the new Stunner AF (Add Fluorescence) from Unchained Labs, which facilitates high-throughput and precise analysis of particle size and encapsulation efficiency. Furthermore, the webinar will delve into the in vitro screening of LNP functionality using the Incucyte^® Live-Cell Imaging System from Sartorius. This technology enables comprehensive screening of the transfection efficiency of different LNP formulations across various cell lines and immune cells, paving the way for the optimization of specific formulations tailored to particular cell types and primary T cells. Join us to discover how these advanced tools and methodologies are revolutionizing LNP research and formulation development.

Key learnings include:

• Streamlined LNP workflow using connected tools for formulation, screening, and analysis
• Rapid LNP screening with Sunscreen HTS and LipidBrick^® cationic lipid library
• Precise characterization of particle size and encapsulation using Stunner AF
• Functional screening of LNP transfection using Incucyte^® live-cell imaging
• Optimized LNP formulations tailored for specific cell types, including primary T cells

A live Q&A session followed the presentation, offering a chance to pose questions to our expert panelists.

Produced with support from: