Members of the Klarman Cell Observatory at the Broad Institute and the Joint Center for Cancer Precision Medicine (CCPM) at the Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and the Broad have embarked on an effort to use single-cell genome analysis to explore the diverse cellular environments of cancer tumors in finer detail than ever before. In this video, researchers involved in a pilot study that looked at melanoma – the most deadly form of skin cancer — describe their methods, their findings, and their hopes for how their approach might inform patient care in the years to come.