New England Biolabs has released the Monarch® Mag Cell-free DNA (cfDNA) Extraction Kit, a bead-based method designed for scalable and reproducible isolation of low abundance cfDNA from plasma, serum, urine, and cerebrospinal fluid. The method supports input volumes from 1 to 4 mL and recovers short DNA fragments using silica-coated magnetic beads and specialized chemistry suited to nuclease-rich biofluids. The kit is compatible with manual or automated processing and aligns with the broader Monarch portfolio through reduced plastic usage and integration with NEB’s downstream sequencing and amplification solutions.