The Biomek NGeniuS workstation is a purpose-built liquid handler for NGS library preparation. It was developed to offer a solution to time-consuming manual transfers and hands-on time for the labor-intensive process of library construction. The Biomek NGeniuS workstation works by combining optical analytics technology—Dynamic DeckOptix system—with a heads-up display to provide users real-time feedback on labware placement. The Biomek NGeniuS Portal software can allow batch sizes from 4–24 samples to be set up and monitored remotely from a Google Chrome- or Microsoft Edge–enabled computer.