German initiative studies human liver cells using a systems biology approach.

Genedata extended its collaboration with the HepatoSys research network by three years. HepatoSys, an interdisciplinary initiative funded in 2003 by several German research centers, aims to understand the physiology and pathophysiology of the human liver cell using a systems biology approach.

In the first funding period of HepatoSys, Genedata was tasked to develop and establish a computational platform to serve as the consortium’s central data storage and analysis infrastructure. The platform—built on Genedata’s Phylosopher® and Expressionist®—was successfully deployed and is now being used by the consortium.

The centralized data storage infrastructure enables an integrative approach to the interpretation of systems biology modeling results in the context of experimental findings, including high-throughput transcriptomics, proteomics, and metabolomics data.

Taking the collaboration to the next level, Genedata will now work on data analysis projects to interpret the huge amounts of molecular profiling data generated within the HepatoSys consortium.

“After having built successfully on Genedata’s track record in developing our scientific computing infrastructure, we see a tremendous opportunity in bringing together our academic expertise with Genedata’s know-how to transfer systems biology applications to the pharmaceutical industry,” remarks Jens Timmer, scientific spokesman for HepatoSys.

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