Panelists:
Phil Clarke, PhD
Associate Director,
Scientific Communications
ChemPartner
Greg Liang, MD, MSc
Director
XDC Platform and Biologics Discovery
Hu Liu, PhD
Senior Director
Biologics Discovery
- Time:
Antibody–drug conjugates (ADCs) have redefined targeted oncology. Yet resistance, tumor heterogeneity, and off-target toxicity continue to limit therapeutic index and long-term durability. As ADCs advance into earlier lines of treatment, smarter molecular design and tighter translational integration are becoming essential to clinical success.
In this GEN webinar, ChemPartner experts Philip Clarke, PhD, Hu Liu, PhD, and Greg Liang, MD, will share practical, data-driven strategies for engineering next-generation ADCs with enhanced efficacy, improved safety, and reduced developmental risk. Drawing on real-world case studies from HER2- and TROP2-targeted programs, they will demonstrate how rational ADC design and integrated preclinical platforms can expand the therapeutic window while improving translational predictability. Key takeaways include:
- Multi-targeting precision: How trispecific, bispecific, and biparatopic antibodies can enhance tumor selectivity, increase internalization and binding avidity, and address tumor heterogeneity.
- Next-generation linker technology: An overview of the C2.LP double-cleavage linker system, engineered to improve in vivo stability and minimize premature payload release and off-target cytotoxicity.
- Overcoming resistance with dual-payloads: Strategies for leveraging dual-payload ADC designs to target complementary cellular pathways and circumvent resistance mechanisms.
- Translational predictability: How integrated in vitro and in vivo platforms enable more confident decision-making from early discovery through IND submission.
This session is designed for oncology R&D leaders, ADC discovery scientists, and translational research teams seeking differentiated platform approaches to accelerate next-generation ADC development.
A live Q&A followed the webinar offering a chance to pose questions to our expert panelists.
Produced with support from:


