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As nucleic acid therapeutics continue to expand and diversify, there is a growing need to achieve higher resolution separations of longer oligonucleotides. Specific examples include characterization and impurities analysis of single guide RNA for gene editing (sgRNA; typically 100-150mer), and mRNA polyA tail analysis to characterize polyA tail length and polydispersity (typically in the 90-130mer range).

In this webinar, Dr. Martin Gilar will review tools and techniques that improve the resolution of long-mer oligonucleotide separations and will demonstrate data obtained for both the characterization and impurities analysis of sgRNA as well as polyA tail length and heterogeneity analysis.

A live Q&A session followed the presentation, offering a chance to pose questions to our expert panelist.

Martin Gilar
Martin Gilar, PhD
Scientific Fellow:
Separations R&D Group
Waters Corporation

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