GEN Exclusives

More »

Best of the Web

More »
Nov 01, 2007 (Vol. 27, No. 19)

Database of Genomic Variants

URL:projects.tcag.ca/variation
  • Unique coverage
  • Nothing significant
Viva la differencia! Such is the theme of the Database of Genomic Variants, which aims “to provide a comprehensive summary of structural variation in the human genome.” In contrast to the interest in SNPs (single nucleotide polymorphisms), the Database of Genomic Variants (DGV) focuses on altered DNA segments that are greater than 1 kb in length. As such, DGV is an important site that provides yet another perspective of human genomic variation. Some of these differences are due to the recently recognized copy number variation and cause human DNAs to vary more than previously thought. As noted at the site, 2,000 copy number variants have been described with thousands more to be described. The average size detected to date is about 250,000 bases. Gulp. These are not small differences, obviously. Not surprisingly, these differences are involved, in some cases, in disease, as well as in rapidly evolving coding regions (for the brain, for example), but not in commonly needed functional domains (cell division, for example). If genetic variation is your interest, DGV needs to be on your radar.
  • Key:
  • Strong Points
  • Weak Points
  • Ratings:
  • Excellent
  • Very Good
  • Good

*The opinions expressed are solely those of the author(s) and should not be construed as reflecting the viewpoints of the publisher, Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., the publishing house, or employees and affiliates thereof.

Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Eyes on the Science Prizes

The proliferation of big-money science prizes might be seen as cheering or worrisome. Where do you stand?