The guava easyCyte™ 12, a flow cytometry system that uses three excitation lasers, can provide 12 simultaneous detection parameters (including 10 fluorescent colors) while consuming less sample and generating less waste. The system also features forward and side scatter for size and granularity determination. It can detect mammalian and microbial cells and beads. Single-sample and multiple-sample processing options are offered, and high-throughput analysis is possible with robotic sample trays that automatically handle 96-well microplates and up to 10 sample tubes. As with other systems in the guava easyCyte line, a sample of fluorescently labeled cells is aspirated into a microcapillary flow cell. In addition, the flow cell is self-aligning and user-replaceable.