Related to Introducing In Vitro ADMET Studies Earlier

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• Cell-Based Kinase Assays
• Cisbio Bioassays
• Three kinase assays are now available as part of a cell-based kinase screening platform. Phospho-STAT3 (signal transducer and activator of transcription 3) (Tyr705), Phospho-p38 MAPK (Thr180/Tyr182), and Phospho-IKKβ (Ser177/Ser181) involve targets
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• Cytotoxicity Assay
• Promega
• The Mitochondrial ToxGlo™ assay helps produce the predictive data necessary to assess mitochondrial function in the context of other cytotoxic events. Based on the differential measurement of biomarkers associated with changes in cell membrane inte
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• Retinoic Acid Assay Kits
• INDIGO Biosciences
• Retinoic acid receptor (RAR) gamma and retinoic-acid orphan receptor (ROR) gamma assay systems are now available in cell-based assay kits that enable researchers to obtain data in four steps: thaw, feed, dose, read. The RORγ and RARγ assay kits can
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• Microplate Reader
• BioTek Instruments
• Synergy™ NEO HTS multimode microplate reader is tailored for smaller cell-based screening assays. Synergy NEO includes multiple parallel detectors to decrease measuring time, and filter-based optics for live-cell assays. The Hybrid Technology™ foun
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• Reporter Kits
• Horizon Discovery
• Available through a partnership with Promega, X-MAN™ reporter kits can enable researchers to apply cell-based assays that directly interrogate critical biological activities at endogenous expression levels. The X-MAN reporter kits are designed for
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• 96-Well Plates
• Reinnervate
• The Alvetex® Scaffold 96-well plates allow scientists to grow tumor cells in a way that mimics the way these cells grow in vivo and test the cytotoxic effect of novel or existing anticancer compounds using standard cell health assays including
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• Transporter Knockout Cell Lines
• Sigma-Aldrich
• MDR1, BCRP, and MRP2 transporter knockout cell lines are now available that enable identification of substrate/transporter interactions without chemical inhibitors or knockdown RNAi technology. The knockout cell lines are available as assay-ready p
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• Incubator for Cell-Based Research
• Thermo Fisher Scientific
• The Cytomat® 10 is an automated incubator and storage module for high-capacity cell growth and assay incubation. It offers environmental control and can be integrated with existing automated assay hardware. A thermal disinfection method can ge
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• Mitochondrial Toxicity Assays
• INDIGO Biosciences
• A new series of assays called the MitoVir platform evaluate mitochondrial toxicity by examining inhibition of the ribonucleoside triphosphates that are substrates for the human mitochondrial RNA polymerase (POLRMT). The MitoVir platform is based on
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• Kidney Toxicity Panels
• Bio-Rad
• Developed through a partnership with Myriad RBM, the Bio-Plex Pro RBM assays enable the detection of multiple biomarkers in a single sample, which may reveal damage within hours of kidney injury. This early detection can improve drug testing in bot