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May 15, Vol. 30, No. 10

  • Feature Articles

    • CGH Delivers Insights on Cytogenetics
    • Richard A. Stein
    • Early efforts to examine genomic changes in the clinical setting relied on cytogenetic techniques such as chromosome karyotyping, a widely used approach to examine chromosomes and identify changes that could be responsible for a specific phenotype This technique is sometimes ... more »
    • Accelerating Small Molecule Research
    • Kevin Hrusovsky
    • While the 21st century has witnessed great strides in the life science research tools industry, it has also witnessed a simultaneous decline in productivity in the pharmaceutical industry, to the extent that small molecule R&D, on average, is currently a ... more »
    • R&D in the Protein Kinase Field Blossoms
    • Elizabeth Lipp
    • Currently, there are only eight small molecule kinase inhibitors approved and on the market; however, researchers have approximately 500 kinase inhibitors working their way through discovery and preclinical phases, thus making protein kinase inhibitors a force to be reckoned with ... more »
    • Tiny but Powerful Tools for Sample Prep
    • Catherine Shaffer
    • Biological research instrumentation is getting smaller and smaller as genetic and biomarker analysis moves out of the laboratory and into the clinic or the field Smaller technologies now available include handheld immunoassay strips, flow assays, PCR systems, and mass spec ... more »
    • Single Use Becoming an Established Tool
    • Angelo DePalma, Ph.D.
    • As single-use bioprocessing approaches its first decade, integration and standardization are on everyone’s short list of desirable features Suppliers are responding with significant initiatives to streamline the specification, acquisition, assembly, and deployment of disposable equipment... more »
    • Pioneering New Collaborative Approaches
    • Margaret A. Kasschau
    • Following completion of the Human Genome Project (HGP) in 2004, the scientific community moved to apply this knowledge to gain a better understanding of human disease Specifically, the analysis of small molecules offered a unique opportunity toward the development of ... more »