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April 01, 2014 (Vol. 34, No. 7)

Screening Mitochondrial Toxicity

New Cost- and Time-Efficient Assay Kits Designed to Profile Compounds

  • Proper mitochondrial function is critical for the maintenance of cellular homeostasis. Under aerobic conditions, the majority of ATP utilized by mammalian cells is generated by mitochondrial oxidative phosphorylation. Through the reduction of oxygen and oxidation of nutrients obtained through metabolic reactions, the electron transport chain (ETC) pumps protons ...

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