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Aug 1, 2009 (Vol. 29, No. 14)

Bioreactor and Fermentor Market Trends

Vaccine and Biopharmaceutical Product Developments Boost Technological Innovation

  • Scale to Meet Demand

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    Labfors 4 bench-scale bioreactors are available in working volumes from approximately 1 to 10 liters.

    Felezeu views newer disposable and traditional CIP/SIP bioprocess systems as being complementary technologies, with disposables meeting market needs up to 1,000 L scale and traditional systems taking over from there.

    The company has longstanding expertise in the development of stainless steel, modular, customized industrial-scale bioprocess systems that are assembled on-site. It also offers a line of laboratory-scale bioreactor systems with autoclavable glass vessels. At its manufacturing facilities in France and the U.S., Pierre Guerin offers customized skid design services and pressure vessels ranging from 5–25,000 L for bioreactor systems and up to 30,000 L for microbial applications.

    Bioengineering’s product offerings range from lab- to pilot- to production- scale fermentors and bioreactors and include autoclavable models and traditional CIP/SIP stainless steel tank systems.

    “All Bioengineering bioreactors—from laboratory to production scale—are of modular design; every newly developed component is designed as a module and can be seamlessly installed in established bioreactors,” explains Karin Koller, Ph.D., a scientific associate at the company.

    Noting that single-use systems have limitations in terms of process control, the possibility of leaching of extractables, mass and heat transfer on scale-up, and the production of waste materials, Dr. Koller contends that, “more expenditure in capital costs, validation and automation for steel fermentors signifies more flexibility for process development and more safety in the production process.

    The Medicel Explorer is a parallel cell culture reactor system that features 15 bioreactors, automated sample withdrawal, and control software. The system contains a cultivation unit that houses 15 independently controlled 200 mL or 500 mL bioreactors, with monitoring and individual control of temperature, pH, and dissolved oxygen, as well as agitation, aeration, and feeding.

    Optional features include gas mixing for three additional gases, a liquid pulse module for rapid feeding and perturbation, gas analysis capabilities, in-line HPLC, and an in-line microscope to perform cell count and viability analyses.

    Infors HT’s Multifors line of benchtop reactors features a modular design to allow for bacterial fermentation at working volumes of 500 mL or 1,000 mL and for cell culture at working volumes of 500 mL and 700 mL.

    The company’s Minifors system combines a shaker flask culture system with probes for process monitoring, and automatically performs data-logging, graphing, and report generation. The Labfors 4 system contains four pumps for independent, computer-controlled operation of multiple bioreactors.

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