Epigenetic Changes in Aging Stem Cells Rejuvenated by Acetate

Thinner bones and more fractures are common ailments of aging. One cause is the reduction of stem cell function caused by changes in the epigenome. More specifically, chromatin remodeling due to degradation of a citrate carrier. Now, researchers show that acetate is a key factor in the reversal of these changes in isolated stem cells—findings that could be relevant for the treatment of diseases such as osteoporosis.