Before CRISPR-Cas9 can be used with confidence in the human body, it must demonstrate that it is safe—and not just with respect to off-target effects, which preoccupy many scientists adapting CRISPR-Cas9 to edit genes in cells in human tissues. Another dimension of safety is immunogenicity toward the Cas9 protein, which is, after all, a foreign … Continue reading CRISPR-Cas9 Goes Immuno-Incognito