Normally, when cells die, including most cancerous cells, it’s through a process called apoptosis, a quiet, orderly death. But if gasdermin E is present and working, cancer cells succumb to pyroptosis, a highly inflammatory death. According to a new study, restoring gasdermin E expression turns cold tumors hot, increasing the number and antitumor functions of tumor-infiltrating lymphocytes and enhancing the phagocytosis of tumor cells by tumor-associated macrophages.