By the end of this week, the world should cross two small but significant milestones on the road to overcoming COVID-19—getting at least 5% of the global population fully vaccinated against SARS-CoV-2, with at least 10% receiving one dose of vaccines that require two. The worldwide march toward vaccination explains why this year is expected to be as good as it gets when it comes to the size of the market for COVID-19 vaccines and drugs. The first authorized drugs and vaccines indicated for COVID-19 generated more than a combined $10.91 billion in sales during the first quarter of 2021—more than double the $4.23 billion generated all of 2020.