An additional approval for ATTR-CM could potentially more than double the peak-year sales potential of patisiran. Under the name Onpattro, the drug racked up $137.009 million in first-quarter net product revenues, up 34% from $101.951 million in Q1 2021, on top of $474.737 million for all of 2021, (up 55% from $306.081 million in 2020). Alnylam is among companies developing ATTR treatments that they hope will someday outcompete Pfizer’s blockbusters of Vyndaqel® (tafamidis meglumine) and/ Vyndamax® (tafamidis . . .

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