Antibodies Targeting S. aureus Sugar Identified as Key to Fighting Infection
Researchers identified a critical immune factor for host defense against Staphylococcus aureus, offering a potential explanation for the failure of previous vaccine strategies. Studies showed that healthy humans generate IgM and IgG antibodies against an S. aureus surface sugar, and found that IgM antibodies were more effective than IgG antibodies at killing the bacteria. Low levels of the IgM antibodies among patients with S. aureus bacteremia correlated with disease mortality and impaired cell killing.
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