Scientists at the Mayo Clinic are testing a new approach to correct metabolic liver disorders without a whole-organ transplant. Their findings (“Curative Ex Vivo Liver-Directed Gene Therapy in a Pig Model of Hereditary Tyrosinemia Type 1”) appear in Science Translational Medicine.

The medical research study tested gene therapy in pigs suffering from hereditary tyrosinemia type 1 (HT1), a metabolic disorder caused by an enzyme deficiency. The common treatment for this disease is a drug regimen, but it is ineffective in many patients, and the long-term safety of using the drug is unknown.

“Liver transplant is the only curable option in treating HT1, which is characterized by progressive liver disease,” says Raymond Hickey, Ph.D., a Mayo surgical researcher. “Using this novel approach to treat HT1 and other metabolic diseases will allow patients to avoid a liver transplant and save more lives.”

Through gene therapy, the corrected liver cells are transplanted into the diseased liver, resulting in enzyme production. “This treatment is a new form of cell transplantation that utilizes the patient's own cells, so it does not require immunosuppressive drugs and, thus, avoids the side effects of those drugs,” adds Scott Nyberg, M.D., Ph.D., a liver transplant surgeon at Mayo Clinic. This therapy resulted in the improvement of pigs with HT1 and the prevention of liver failure. The use of nuclear imaging enables the researchers to monitor expansion of the corrected cells through a noninvasive imaging process.

“Pediatric patients suffering from inborn errors of metabolism of the liver will benefit most from this therapy,” says Dr. Hickey. “More than one-fifth of all pediatric liver transplants are a result of metabolic disease.”








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