CRADA includes Phase I trial with in melanoma and further research on T-cell receptors.


Ortho Biotech Oncology Research & Development entered into a five-year CRADA with the NCI to research and develop cell therapies for cancer. The company will work with Steven A. Rosenberg, M.D., Ph.D., chief, surgery branch.

Ortho Biotech’s has developed an adoptive immunotherapy approach that uses tumor antigens and other materials to stimulate T cells from a patient’s blood to become cytotoxic T lymphocytes, which recognize and attack tumor cells.

Under the CRADA, Dr. Rosenberg’s lab will conduct a clinical trial in melanoma patients using Ortho’s adoptive immunotherapy. This is expected to begin toward the end of the year. The other part of the CRADA will focus on a T-cell receptor (TCR) research program.


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