The Cobra Biologics spinout Prokarium acquired Emergent BioSolutions’ live Salmonella-based typhoid vaccine Typhella™, and oral delivery platform spi-VEC™. Emergent has previously carried out Phase I and II clinical studies demonstrating that Typhella is safe and immunogenic as a typhoid vaccine.

Prokarium has combined the Typhella and spi-VEC technologies with its own ORT-VAC™ (Operator-Repressor Titration for Vaccines) plasmid stabilization technology to generate a salmonella-based Vaxonella™ platform for the oral delivery of recombinant protein vaccines.

The Vaxonella platform is being commercialized through licensing agreements, and Prokarium is focusing its own in-house research on the development of a dual oral vaccine candidate Typhetec™ against typhoid and ETEC (enterotoxigenic E.coli). Clinical trials with Typhetec are projected to start during 2013.

Prokarium’s ORT-VAC™ technology (Operator-Repressor Titration for Vaccines) is the only selectable marker-free plasmid stabilization technology that can function with any type of plasmid, enabling recombinant antigens to be delivered orally.








This site uses Akismet to reduce spam. Learn how your comment data is processed.