BU1/75 can be used to detect cell proliferation and cytokinetics.
AbD Serotec signed a license agreement with The Institute of Cancer Research (ICR), London for worldwide, exclusive rights to commercialize the prototypic and most popular Bromodeoxyuridine (BrdU) antibody clone for research applications. The agreement covers clone BU1/75 (also known as ICR1), allowing development in various formats suitable for applications such as ELISA, flow cytometry, and immunohistochemistry.
“With this agreement AbD Serotec will become the sole supplier of this important BrdU antibody, a powerful tool to detect cell proliferation and cell kinetics assays,” comments Dieter Feger, head of AbD Serotec. “This product complements our comprehensive range of high-quality cell biology reagents covering key research areas such as apoptosis, cancer, cell signaling, and cell morphology.”
BrdU—an analog of the DNA base thymidine—is a reagent commonly used in the detection of proliferating cells in living tissues and tissue samples. During DNA synthesis, BrdU can be incorporated into the newly synthesized DNA of dividing cells.
Subsequent detection of BrdU incorporated into DNA using antibodies is a powerful tool for studying the cytokinetics of normal and diseased cells. In vitro or in vivo labeling of tumor cells with BrdU and the subsequent detection allows easy and rapid analysis of tumor-cell growth kinetics with high accuracy, AbD Serotec reports.