Tumors Change Nearby Immune Cells to Promote Tumor Growth

Researchers used single-cell RNA-seq to characterize the immune composition of an undifferentiated pleiomorphic sarcoma mouse model. They discovered that cancerous tumors, called soft-tissue sarcomas—which kill more than 5,000 people in the United States each year—produce a protein that switches immune cells from tumor-attacking to tumor-promoting. These data could pave the way for testing new therapies that are aimed at re-shaping the sarcoma microenvironment.