Bridge Therapy for Children with High-Risk Neuroblastoma

Neuroblastoma can often be cured by surgical removal of tumors followed by chemotherapy. Patients often receive induction therapy composed of various chemotherapy drugs and surgery, followed by consolidation therapy. Unfortunately, these standard treatments are unsuccessful in many children. A bridge therapy, which might include immunotherapy drugs that have demonstrated anti-neuroblastoma activity combined with chemotherapy, radiolabeled MIBG, or combinations of chemotherapeutic agents, could offer some benefit.