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Infectious Diseases

Universal Flu Vaccine Candidate Exploits Conserved Domains

Scientists at Georgia State University have designed a universal flu vaccine that protects against both influenza A and B virus types and successfully tested its efficacy in young and aged mouse models. The vaccine is a virus-like particle (VLP) that includes a baculovirus vector that expresses several subtypes of neuraminidase and tandem repeats of a highly conserved, extracellular segment of a protein called M2e that stimulates the host’s immune system.