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Trojan Horse Antidotes Designed to Neutralize Lethal Botulinum Toxin

Botulinum neurotoxins (BoNTs) are classified by the United States Centers for Disease Control and Prevention (CDC) as one of the most dangerous bioterrorism agents. BoNTs infiltrate into motor neurons, block neurotransmitter release, and stop essential functions such as breathing. Two independent studies have used nontoxic derivatives of BoNT to deliver therapeutic antibodies that bind and neutralize these toxins within neurons.

Chemotherapy Poised to Deliver a Double Punch

Combining the chemotherapy drug, Gemcitabine, with the anti-inflammatory drug, Celecoxib (Celebrex), triggers immune response, increasing treatment efficacy in cell and animal models.

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