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Bioinformatic Study Underscores Contribution of Tandem Repeat Mutations in Autism

Scientists use bioinformatic tools to demonstrate tandem repeats may contribute to ASD. The study demonstrates a significant genome-wide increase of tandem repeat mutations in children with ASD. The study shows TR mutations in affected children are larger, enriched in fetal brain regulatory regions, and predicted to be more evolutionarily deleterious compared to mutations observed in unaffected siblings.
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