Home Tags Sexual dimorphism

Tag: sexual dimorphism

Chronic Pain is Processed Via Sex-Specific Conserved Mechanisms

Building on their earlier studies that developed a new ex vivo human spinal pain model from donor tissue and reported the conservation of a spinal pain signaling pathway across male rats and humans, a team of collaborating Canadian scientists now show this pain pathway is sexually dimorphic, and the sexual dimorphism is also conserved across species. This study is the first to identify a sex-related difference in pain signaling in human spinal cord tissue bolsters future precision medicine approaches in the treatment of chronic pain.

Stress before Birth Affects Midlife Brain Circuits Differently in the Sexes

Exposure to inflammation promoting cytokines in the womb generated due to maternal stress during pregnancy differentially affects stress and immune regulatory brain circuitry in male and female offspring and retained into midlife. The study demonstrates a need for sex-dependent targets and therapeutics for early therapeutic intervention and prevention in neuropsychiatric disorders such as bipolar disorder, schizophrenia and major depression.