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Immunotherapy Co-Opts Physically Interacting Cells in Lung Tumors

A new study defines a key subset of cells called ThT cells that express the markers CD4, PD-1 and CXCL13. In the microenvironment of human lung cancer ThT cells physically interact and directly communicate with antigen presenting dendritic cells to protect tumor cells from the body’s anti-tumor immune response. The authors also show how immunotherapy that utilizes the immune checkpoint inhibitor anti-PD-1, co-opts these cells to kill tumor cells.

RNA Sequencing Improves Gene Fusion Detection in Childhood Cancers

A single test that scans the entire tumor RNA landscape increases the detection of gene fusions nearly one and a half times in childhood cancer, a new study from investigators at the Princess Máxima Center for Pediatric Oncology in the Netherlands has found. RNA sequencing, the authors expect, will soon replace traditional diagnostic methods as genetic abnormalities in childhood cancer can be immediately included as part of new diagnoses allowing patients to benefit as quickly as possible from new findings in basic research.

Liver Cancer Biomarker and Gene Signature Discovered in New Prognostic RNA...

New research in the journal Aging-US takes a closer look at the competitive endogenous RNA regulatory network to better understand complex gene interactions in hepatocellular carcinoma (HCC) and identify potential biomarkers to diagnose and treat HCC. Using RNA sequencing data available in public TCGA and GEO databases, they establish a seven-gene HCC signature and validate one hub gene in the prognostic signature, DTYMK, as a new potential biomarker.

Unexpected Rich Diversity in Neurons That Control Movement, NIH Study Reveals

Researchers at NICHD led by Claire Le Pichon, PhD, adopt a novel targeted single nuclear RNA sequencing approach to classify mouse cholinergic motor neuron subtypes based on transcriptomic diversity, and provide an atlas of adult mouse motor neurons to pinpoint neurons involved in neurodegenerative diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis.