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Liver Cancer Biomarker and Gene Signature Discovered in New Prognostic RNA...

New research in the journal Aging-US takes a closer look at the competitive endogenous RNA regulatory network to better understand complex gene interactions in hepatocellular carcinoma (HCC) and identify potential biomarkers to diagnose and treat HCC. Using RNA sequencing data available in public TCGA and GEO databases, they establish a seven-gene HCC signature and validate one hub gene in the prognostic signature, DTYMK, as a new potential biomarker.

Unexpected Rich Diversity in Neurons That Control Movement, NIH Study Reveals

Researchers at NICHD led by Claire Le Pichon, PhD, adopt a novel targeted single nuclear RNA sequencing approach to classify mouse cholinergic motor neuron subtypes based on transcriptomic diversity, and provide an atlas of adult mouse motor neurons to pinpoint neurons involved in neurodegenerative diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis.