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Diabetes Drug May Also Reduce Risk of Alzheimer’s Disease

A new study provides evidence that interventions on pathways targeted by diabetes medications may also reduce the risk of Alzheimer’s disease (AD). The study investigates the association between the risk for AD and genetic variation in the targets of four classes of anti-diabetic drugs. The researchers identified genetic variants that mimic the drug target for diabetes drugs by searching through biobank data and performing validation analyses using genotype data, in a Mendelian randomization study design.

Breast Cancer Drugs Can Be Repurposed for Cancers with Splice Mutation

Scientists at the Queen’s University of Belfast and the University of Birmingham have found a variety of cancers with mutations in the SF3B1 gene that forms part of the cellular splicing machinery respond to existing drugs that inhibit the enzyme poly ADP ribose polymerase (PARP). Currently PARP inhibitors used to treat cancers with mutations in the BRCA1 and BRCA2 genes. With PARP inhibitors already widely available, the study indicates it may be possible to treat patients with rare and difficult-to-treat cancers bearing mutations in SF3B1, using these repurposed drugs.

Asthma Worsens with Repurposed Drug Licensed for Psoriasis

A medicine used to treat psoriasis worsens asthma symptoms in patients with severe asthma, according to a randomized, placebo-controlled, double-blind, clinical trial result published in the New England Journal of Medicine. The drug risankizumab, a humanized, monoclonal antibody, targets the proinflammatory cytokine IL-23. IL-23 inhibition has been an effective treatment strategy for psoriasis and Crohn’s disease. Molecular profiling of sputum samples showed the drug reduced factors that prevent infections in airways.

Natural Drug Approved for White Blood Cell Recovery Can Be Repurposed...

Fortuitous research probing the reasons why patients with rheumatoid arthritis do not get Alzheimer’s disease, has led researchers to identify an FDA approved natural protein, Sargramostim/GM-CSF, as a drug that can be repurposed to improve cognition and reduce brain amyloid, tangles, neurodegeneration, and blood biomarkers of Alzheimer's disease.