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Chronic Pain is Processed Via Sex-Specific Conserved Mechanisms

Building on their earlier studies that developed a new ex vivo human spinal pain model from donor tissue and reported the conservation of a spinal pain signaling pathway across male rats and humans, a team of collaborating Canadian scientists now show this pain pathway is sexually dimorphic, and the sexual dimorphism is also conserved across species. This study is the first to identify a sex-related difference in pain signaling in human spinal cord tissue bolsters future precision medicine approaches in the treatment of chronic pain.