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Psoriasis Therapeutic Could Tweak an Alternate Target in a Trio

Mice having a keratinocyte-specific deletion of the receptor for the cytokine TWEAK, Fn14, display reduced skin inflammation upon chemical induction, including decreased epidermal hyperplasia and less expression of psoriasis signature genes. Based on this finding and transcriptomic analysis of human keratinocytes, Michael Croft, PhD, and his team have shown TWEAK works together with the known cytokines TNF or IL-17 in provoking inflammation in psoriasis. The study shows targeting TWEAK could offer an alternative approach to treating the disease.