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Sequencing Aggressive Cells Identifies Targets in Heterogenous Cancers Expeditiously

A collaborative team of scientists in the Netherlands have developed a new technology to select aggressive cancer cells from a heterogenous biopsy sample and sequence them individually to link genomic or transcriptomic profiles with functional cellular characteristics. The new technology could help unravel molecular mechanisms driving the growth of tumor-cell subpopulations much faster than existing technologies. The platform includes a custom-built ultrawide field optical microscope, fast automated image analysis and a visible-light-activatable dye.