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Complete Temporal Genetic Series Identified in Fly Visual System

A new study has determined a complete series of temporal transcription factors in the optic lobe of fruit flies. The study provides mechanistic insights into how the temporal protein series is regulated, and how they can lead to the generation of a complete set of neurons in the fly visual system. Impairment of the temporal series reduces neuronal diversity and alters brain development. The authors also show initial neuronal differentiation is comparable in fly and human cortical neurons.