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Unexpected Rich Diversity in Neurons That Control Movement, NIH Study Reveals

Researchers at NICHD led by Claire Le Pichon, PhD, adopt a novel targeted single nuclear RNA sequencing approach to classify mouse cholinergic motor neuron subtypes based on transcriptomic diversity, and provide an atlas of adult mouse motor neurons to pinpoint neurons involved in neurodegenerative diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis.