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Molecular Switch Identified That Flips from Self-Renewal to Specialization in the...

Scientists decipher the mechanisms by which beta-catenin, a co-activator of the developmental molecular pathway called Wnt signaling, regulates both self-renewal and specialization during the developmental program that leads to the formation of a kidney. The study reports raised levels of the co-activator flips the switch from self-renewal to specialization by replacing transcription factors at primed gene targets.

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