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Pancreatic Cancer Signatures Revealed in Large-Scale Multiomic Study

To identify better therapeutic targets and biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC), a highly aggressive form of cancer with poor prognosis, scientists have taken a multiomic approach. They utilized methylation studies, whole-genome and whole-exome sequencing, and RNA and microRNA sequencing on the same tissues to achieve an integrated understanding of the effect of genomic changes on protein expression, signaling pathways, and biochemical modifications of proteins that have been synthesized.